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Decrease in mucosal secretion is thus considered important in gastric ulceration (Goel and Bhattacharya, 1991) [ 28].
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Similarly, IgA antibodies were detected in the mucosal secretions, with OD490 values of 0.9 and 1.7 (ratio 0.5) for 1 2 diluted fecal samples and VWs, respectively (Fig. 1C).
Quantifying HIV levels in mucosal secretions is essential to study compartmentalized expression of HIV and facilitate development of intervention strategies to prevent disease progression and transmission.
Immunoglobulin transport may enrich mucosal secretions for IgA, but the IgA response to MHV-68 is minimal [45] and much of the KSHV-specific antibody in mucosal secretions is IgG [46].
The role of IgG in mucosal secretions is controversial, since this isotype can act both as a protective mechanism and as a cytotoxic mediator due to its ability to activate complement proteins and induce antibody-mediated cytotoxicity via polymorphonuclear leukocyte Fc receptor, which would damage mucosal epithelium [ 54].
We focussed on serum antibody, but the specificities in mucosal secretions are unlikely to be substantially different.
Mucosal secretions were not tested for the presence of anti-viral antibodies, and it is therefore possible that mucosal but not systemic antibodies were induced by chemo-vaccination.
After three rounds of immunization, the PspA-specific antibody responses in both the serum and mucosal secretions were measured.
Methods: Murine duodenal mucosal HCO3− secretion was examined in vitro in Ussing chambers and mucosal SLC26A6 expression levels were analyzed by semiquantitative reverse-transcription polymerase chain reaction.
Duodenal mucosal alkaline secretion was measured in methohexital- and α-chloralose-anaesthetised rats by means of in situ pH-stat titration.
The present study confirms that intravenous administration of the peptidergic compound CGP42112A stimulates duodenal mucosal alkaline secretion suggesting that this secretion is under the control of the RAS [ 3].
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