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Ten Rhesus macaques were infected with the SIV via intravenous injection and ten macaques were infected via a mucosal route of infection, mimicking sexual transmission.
The mucosal route of vaccine delivery has been considered for a number of reasons including direct targeting of sites where the effects of given antigen or adjuvant are needed.
However, mounting evidence suggests that the mucosal route of vaccination is superior to parenteral vaccination in protecting mucosal surfaces [21].
Thus we can conclude that a mucosal route of antigen delivery is required in order to prime local immune effectors.
These data, showing the expansion and dissemination of antigen-specific primed T cells following intranasal vaccination, demonstrate that the mucosal route of immunization via the respiratory tract can be very efficient in vaccine priming.
We used TLR ligands as adjuvants, immunizing via a mucosal route of administration to evaluate the potential of a novel therapeutic vaccination regimen performed during ART to enhance host control of viral replication following discontinuation of antiretroviral drug therapy.
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Major efforts are made to develop new mucosal candidate vaccines by selecting appropriate antigens with high immunogenicity, designing new mucosal routes of administration and selecting immune-stimulatory adjuvant molecules.
Here, we will discuss data that compare different mucosal routes of immunization to generate B-cell and T-cell responses in the genital tract, with a special emphasis on the newly described sublingual route of immunization.
MVTT offers greater advantage than MVA for inducing high level of systemic Nab response against SARS-CoV through mucosal routes of vaccination.
The current study investigates the production of IL-22, and the role that IL-22 plays during primary and secondary LM infection, using both systemic and mucosal routes of infection.
Most current immunization procedures are obtained by parenteral injection and only few vaccines are administered by mucosal route, because of its low efficiency.
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