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Since this population constitutes the largest cohort of the mucositis at-risk population, the potential beneficial impact of an effective agent for mucosal protection is significant.
The exact mechanism of PPI-induced gastric mucosal protection is not known though.
For this reason, gastric mucosal protection is an alternative treatment for these patients.
Mucosal protection is particularly relevant in the context of respiratory pathogens where their major portal of entry is frequently the nasal mucosa [ 12, 13].
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The current postulated role of gastrokine-1 in mucosal protection was deduced from its cellular localisation in the gastric epithelium.
Down regulation of this protein in gastric carcinoma was postulated to be responsible for several diseases affecting the stomach [1], [27], but only the potential role of gastrokine-1 in mucosal protection was proposed.
Moreover, the present observations on mucosal protection are clearly distinct from longer-term effects of PAI-1, for example, in promoting fibrogenesis as occurs in other organs (14).
Fourteen identified high-risk exposures (potential exposure through unprotected mucous membrane, broken skin, or respiratory route), among whom self-reported use of PPE (respiratory droplet and mucosal protection) was low (7%).
We therefore investigated the relative contribution of CD4+ T cells in the development of the mucosal protection that is conferred by the BHN97Δ ftsY vaccine.
The specific role of mucosal IgA in HIV protection is still under discussion, and the marked differences observed among various cohorts and in different laboratories undoubtedly contributed to confusion.
In addition, they also help in recycling antioxidants like vitamin E and vitamin C. The decrease in endogenous thiol (glutathione) in ethanol induced gastric injury, and its role in mucosal protection has been demonstrated [ 27].
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