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To mimic the route of infection in humans, we utilized an oral mucosal model of infection in mice.
The development of a mucosal model of candidiasis in a transparent vertebrate is especially important because it enables the study of intravital interactions of the pathogen with epithelial and innate immune cells.
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Our findings suggest that IL-22 is not required for clearance of LM during primary or secondary infection, using both systemic and mucosal models of infection.
The study employed a three-dimensional (3D) human-derived oral mucosal model to assess the biocompatibility of base-metal dental casting alloys ubiquitous in fixed prosthodontic and orthodontic dentistry.
This chapter reviews the studies using three-dimensional human oral mucosal models to investigate oral mucosal diseases.
Specifically, in our previous study in a human nasal mucosal model we found that the combination of these two herbs suppresses PGD-2, histamine, IL-5 and pro-inflammatory cytokines equal to or better than fluticasone nasal spray [17].
The aim of this study was to evaluate the biological effects of three different composite resin systems on a three-dimensional human oral mucosal model.
Application of biologically relevant mucosal models can advance understanding of the functional properties of antibodies that mediate HIV protection, thereby guiding antibody-based vaccine development.
We utilized a mechanistic IL-13-driven model and a house dust mite allergen mucosal sensitization model of allergic airway disease to investigate the role of alveolar macrophages in regulating pulmonary inflammation.
Similar to the normal in vivo situation, we found αv β6 expression localised to the basal cells of the mucosal models even though flow cytometric analysis showed abundant cell surface expression on all epithelial cells before seeding onto the DED, showing that 3D culture alters the expression pattern of these molecules.
Tissue-engineered human oral mucosal models have been developed for biocompatibility assessment of biomaterials.
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