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The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity.
While the gut mucosa represents a normal microenvironment, it can also become imbalanced in the context of inflammatory bowel disease.
Intestinal mucosa represents a tissue particularly sensitive to changes in FA environment [8].
It remains speculative, however, whether paranasal sinus mucosa represents a site of HBoV persistence.
28 Due to a large population of activated CXCR4+ CCR5+ target cells, the gastrointestinal mucosa represents a favored target for HIV-1 infection 29 and appears to support enhanced HIV-1 replication in comparison to other body compartments.
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The above data led to a relevant question, i.e. does the incomplete normalisation of the intestinal mucosa represent a risk factor for CD complications?
The oral cavity and its mucosa represent an attractive region for local and systemic applications of many active pharmaceutical ingredients.
Resulting from an increased cell proliferation at colonic crypts bordering the anastomotic line [ 4], an increased cellular activity near the anastomosis [ 23], and from a chronic inflammatory effect by suture [ 5- 9, 33], the hypothesis of a higher susceptibility of the anastomotic mucosa represents the most favourable explanation for these recurrences.
The mucosa represents the primary target site and thus the first barrier for most microbial pathogens.
Therefore dysplasia of the gastric mucosa represents the only universally accepted precancerous lesion of GC.
Therefore, early detection of polyps or colorectal carcinoma before invasion into the surrounding mucosa represents the best hope of reducing colorectal carcinoma-associated deaths.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com