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In contrast, calm2, cnn1, and smoc2 were preferentially expressed in the bladder mucosa of control mice.
The gastric mucosa of control rats showed normal architecture with perfect intact structures and regular epithelial lining (Fig. 4a).
As shown in Figure 2a, mRNA for both APN and leptin was expressed in the mucosa of control and IBD patients.
Nevertheless, we examined how the ME candidates identified in this study compare with genes whose expression correlated with DNA methylation variation in the colonic mucosa of control children.
As shown by the immunohistochemical staining, β-catenin was localized at the membrane of epithelial cells in colonic mucosa of control animals.
Consistent with this notion, the mtDNA sequences obtained from the colorectal mucosa of control subjects showed extensive mutation, although mtDNA in the livers from normal subjects showed no sign of mutation (Nishikawa et al, 2001).
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To evaluate increased oxidative stress in UC, the levels of 8-OHdG in mucosa of controls and UC without cancer were analysed.
In the active phase of UC and CD, significantly lower concentration of amino acids (isoleucine, leucine, valine, alanine, glutamate, and glutamine), membrane components (choline, glycerophosphorylcholine, and myoinositol), lactate, and succinate was observed compared to normal mucosa of controls.
Principal component analysis of DNA methylation data revealed that patients with tumors in the left side of the colon tend to have distinctive methylation profiles, while those with tumors in the right side overlap with both right and left colonic mucosa of controls (Additional file 1: Figure S4).
h, i Jejunal mucosa of a control and GABA-treated rat showing normal Paneth cells with its characteristic granules stained greenish blue (×200, ×400).
Open image in new window Fig. 5 Photomicrographs of jejunal sections showing distribution of mucopolysaccharides in the jejunal mucosa of the control and treated groups (PAS).
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