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Three hundred and 53 showed decreased expression in UC mucosa compared with controls (Table S5).
These data are fully supported by our findings describing lower Rac1 presence in normal mucosa compared with tumour tissue.
Therefore, we performed bump-hunter analysis to identify differentially methylated regions (DMRs) in pediatric IBD colonic mucosa compared with controls.
In this study, the CDH1, gene of E-Cadherin, decreased significantly in the inflamed mucosa compared with adjacent normal control (28±67 versus 119±121, P=0.002).
Furthermore, western blotting analysis showed that the expression of PUMA in PHG was significantly upregulated in the gastric mucosa compared with the normal tissues.
The percentage of BrDU+-proliferating cryptic cells was markedly enhanced in TNBS-inflamed mucosa compared with the vehicle (P<0.01; Figure 4).
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The relative risk of gastric cancer is 1.7 in subjects with moderate gastric mucosa atrophy and 4.9 in those with severe gastric mucosa atrophy compared with those with no or mild gastric mucosa atrophy [ 2].
The villus height was increased (P<0.01) and crypt depth decreased (P<0.05) at the small intestinal mucosa as compared with the control.
Immunoreactivity of the mucosa was compared with the use of anti-mucin monoclonal antibody.
Propofol reduces small-vessel perfusion and increases the heterogeneity of circulation in the sublingual mucosa, when compared with the use of midazolan in septic shock patients.
Moreover, the number of Ki-67-positive proliferating cells increased in the dysplastic mucosa when compared with that in the adjacent normal region.
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