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For Le Vay, the significance of Selye's work lay particularly in its application to broader social issues: Selye's work is important, not only in the narrow biological field of injury and response to injury, but in relation to the much wider problems of man as a living organism set in the stresses of modern civilisation, so many and so varied and so constant in their impact.
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And it's an aspect of a much wider problem.
The Novartis case illustrates a much wider problem in the pharmaceutical industry.
The rural schools in South Carolina are symptoms of a much wider problem.
Lewis Coates, team leader, said: "This investigation was potentially only part of a much wider problem.
It has since emerged that Mr. Goodman sent Mr. Hinton a letter that year reporting a much wider problem.
I'd argue that there is a much wider problem, a cultural problem, illustrated by Darling's implied parallel with the leadership of RBS before the crash.
Those figures, combined with its own forthcoming research, are enough to convince Wada that the sport still has a much wider problem than testers can currently establish.
The report said the suicide last year of Lucy Meadows, a primary school teacher who was transgender, after two previous attempts was indicative of a much wider problem.
"But we can't do this for ever, and in London we face the much wider problem of poor air quality every day.
For those of us who experience disfigurement-related hate crime, these statistics just scratch the surface of a much wider problem.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com