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The role of environmental risk factors and their interaction with genetic susceptibility alleles are much less well defined, despite the fact that infections have long been associated with MS development.
The usually fixed attachment angle of myosin to the actin filament is much less well defined with a random deviation of about 15° in the presence of the mutation for both apo and ADP states.
However the sense of touch, which is conveyed by general somatic sensory neurons, is much less well defined.
In all cases, the circles formed in the spectral embeddings are much less well defined than in the WT specimens, as demonstrated by the histograms in the figures.
Although the concept of multidisciplinary teams is now well established, the interaction between members of the teams is much less well defined, particularly as to who is responsible for managing patients through the diagnostic pathway.
The regulatory component of the human genome is much less well defined but based upon conservation is 2 to 3 times larger than the coding region (Cooper et al., 2010).
All these factors are found to be enriched in lamellipodial protrusions, sometimes with significant spatial variations (Small et al, 2002), but their turnover rates in steady-state protrusion of live lamellipodia are much less well defined.
The p53 tumor suppressor protein plays a crucial role in influencing cell survival in response to cellular stress and while the p53 pathway is considered a key determinant of anti-tumor responses in many tumors, its role in cell survival in MB is much less well defined.
Their positions were generally much less well defined than for the other motifs although the InR and CAT box tended to be more common near to the TSS while the CreA and AreA motifs tended to be more common between -50 and -100 (Additional file 1).
Unlike the fur of the striped and brown hyena, that of the spotted hyena consists of spots rather than stripes and is much shorter, lacking the well defined spinal mane of the former two species.
