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In this interpretation, genes with lowest noise have been most strongly selected against noise, whereas high noise genes have experienced much weaker selection against noise.
This is consistent with a much weaker selection against plausible NAGNAG creations in nematode CDS.
In contrast, Andolfatto [ 17] inferred much weaker selection by fitting genome variability data in D. melanogaster to a recurrent sweep model, and estimates Ne s ~ 40.
Conversely, by freeing themselves from genome size constraints, typical eukaryotes can actually conserve long evolved genes in their own genome under much weaker selection pressure and smaller population sizes than prokaryotes.
The slow recovery of genetic traits discussed above results from much weaker selection pressures for reverse evolution, which implies that even relatively low fishing mortalities are still likely to outweigh those weak pressures and hence hinder recovery.
This might indicate that a balance of large and small amino acids are preferred under elevated expression in P. hawaiensis, that codon and amino acid usage are subject to much weaker selection outside the highest expressed gene set (see Genome-wide optimal codon usage), or that factors other than protein size play a predominant role in shaping amino acid frequency in this organism.
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As Williams [ 48] argued, selection at levels higher than the individual is much weaker than selection at the level of individuals for the following reason.
The fact that young non-disease genes evolve at a much higher rate and are subject to much weaker purifying selection supports this possibility.
While it is possible that some synonymous sites experience selection, it is much weaker than the selection at non-synonymous sites for genes evolving after recent duplication.
Since plausible NAGNAG sites in nematodes are rarely alternatively spliced [ 4, 19], we would expect a much weaker or no selection against the creation of plausible NAGNAG sites.
The much weaker evidence for positive selection in algae and aquatic land plants growing in more stable conditions, compared to terrestrial land plants, suggests that the later explanation is more probable.
More suggestions(15)
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