Unexpectedly, HepG2 achieved much weaker induction of CYP1A1, CYP2D6, CYP2C9 and CYP2C19 in response to rifampicin, dexamethasone and omeprazole than did hepatocyte-like cells.
For example, among the differentially induced immune genes, LPS caused a much weaker induction of the interferon-stimulated protein ISG20 and the NO synthase NOS2 in Tyk2-/ than in Wt cells, but a stronger induction of IFI47 and IRF7 relative to Wt.
In DAB2 expressing C666-1 cells, a much weaker c-Fos induction was observed compared with vector-transfected control cells.
For example, Prospect Hill virus (PHV), a New World hantavirus which has not been identified as a human pathogen, induces a strong IFN response, whereas the induction by ANDV is much weaker, likely correlating with their IFN antagonism efficiencies and possibly their pathogenic potential [29].
In addition, because the GUS activity in PT2 was much weaker than PT1 in the leaves, the induction of GUS activity was visible in the PT2 leaves.
This suggests that the plant's volatile response to the two herbivores is not fundamentally different, although the induction by E. variegatus was much weaker on a per capita basis.
In contrast, activity of the Group-II genes in INIAP12 was several fold lower compared to CT6748-8-CA-17 allall time points, thus cold induction in this cultivar was much weaker and in some cases appeared transient.
However, in contrast to the previously observed reaction of fou2 to wounding [ 17], further induction of these transcripts upon infestation was much weaker than observed in wt plants.
However, this correlation is much weaker when limited to genes that are weakly induced (2-fold or less induction in both our data and the microarray data; r = 0.0429, P = 0.0388), and much stronger when limited to genes that are strongly induced (greater than 2-fold induction in both datasets; r = 0.5053, P = 0.002).
The induction of the wound-specific JA responses in aphid-infested plants is therefore much weaker than in mechanically wounded plants.
In contrast, the single retinoid agents did cause apoptosis in SKBR3 cells, with 4-HPR having a much weaker effect compared with the other retinoids; the addition of trastuzumab to the retinoids produced a small enhancement in the induction of apoptosis.
