Sentence examples for much weaker binding from inspiring English sources

Efforts to use lectins such as lens culinaris and Pisum sativum agglutinin, which will not bind outer arm fucosylated glycan, in the lectin FLISA proved problematic because these lectins have much weaker binding affinities and do not actually bind fucose directly.

IGFs and insulin are proficient to cross-bind to each other's receptor, although with much weaker binding affinity than that for the preferred ligand [ 33, 34].

R9 showed much weaker binding to the artificial membrane (EC50 > 10 mM), whereas Tat did not bind at all.

We show that activities of the potent bivalent inhibitors of thrombin can be reversed by the specific, but much weaker, binding of the linker moiety to protein 'antidotes'antidotes

Presumably, it is due to its much weaker binding affinity (1.4 µM) than BDNF (Kd ∼10−10 M).

In contrast, the engineered knottin peptides only weakly inhibited U87MG cell adhesion to fibronectin, with IC50 values greater than 1 µM (Figure 3B and Table 1), reflecting their much weaker binding to α5β1 integrin.

For example, both combinations containing N59D show a much weaker PEP binding, while those containing A158T show a slightly improved Fru-6-P binding.

Furthermore, ChIP assay also demonstrated that Hand1-DD had a much weaker DNA binding ability than Hand1-WT and -AA (Figure 5C).

This particular order of binding reactions was chosen for the formation of the trimeric complex since previous measurements have shown that FGF2-FGFR binding is much weaker than the binding of FGF2 to HSGAG.

Furthermore, CAND1 binding to Cul1 in vivo is much weaker compared to binding of substrate receptors.

Our data are consistent with that reported by Asher et al. [16] who found that the binding of Nedd4-2 WW-domains to SGK was much weaker than their binding to ENaC, although no affinity constants were reported.