As described, the application of the pure SDM only allows for the statistical quantification of uncertainties.
There is much statistical literature about penalization-based methods.
These different chapters highlight a need for standardization regarding the metrics used for data presentation, parameters definition and statistical quantification.
To overcome the limitations of insufficient statistical quantification of uncertain parameters, this paper treats uncertainties as non-probabilistic intervals.
Statistical quantification of BiFC signals with mutated AbdA proteins is shown as a boxplot representation.
No statistical quantification is provided in the case of a new interaction (as seen with Krüppel).
No statistical quantification is provided in the case of a new interaction (as seen for Knot).
Statistical quantification was performed by a Student's t test for paired groups.
We have added the statistical quantification of this experiment and commented on the comparison in the Discussion.
Yet, this area needs much more statistical work and investment.
