Sentence examples for much smaller trials from inspiring English sources

The distressing results clouded the prospects for the Sept. 24 FDA hearing on Iressa, even though the proceeding was to be based only on the better results in the two earlier and much smaller trials.

The only existing randomized trial evidence after 10 years comes from much smaller trials; the 14-year follow-up of the Danish Viborg trial did not report on ruptured AAA among those screened normal 10, whereas the 15-year follow-up of the UK Chichester trial suggested a possibly substantial increase in ruptured AAA during later follow-up 11.

Of the two trials conducted in patients after cardiac surgery, Van den Berghe and colleagues found a mortality benefit [ 21], but the much smaller trial by Chan and colleagues did not [ 34].

Companies applying for humanitarian device approval can conduct much smaller clinical trials — Second Sight submitted data on only 30 patients — and must only demonstrate safety and "probable benefit," not proof of effectiveness, Dr. Eydelman said.

As indicated in the text, there may be strategies for patient recruitment that would permit doing much smaller clinical trials.

Another issue with clinical trial design is that better selection of septic patients (such as those entering into septic shock) might allow for much smaller clinical trials.

5 The only existing evidence from randomised trials after seven years comes from the much smaller Chichester trial, 8 in which a possibly substantial increase in ruptured abdominal aortic aneurysms among participants screened as normal was noted during later follow-up.

For studies of the use of an AI after 2 3 years of tamoxifen, hazard rates of 0.70 have been reported for the IES study using exemestane (Coombes et al, 2004a, 2004b), 0.60 for the ABCSG8/ARNO95 trial (Jakesz et al, 2005a) and 0.46 for the latest update of the much smaller Italian trial using anastrozole in node-positive women only (Boccardo et al, 2005).

A comparable, but much smaller, randomized trial of 63 patients found similar results (13).

1, 21, 22 Of interest, a second much smaller randomized trial that compared single agent carboplatin to the combination of carboplatin plus PLD revealed a similar strikingly lower incidence of carboplatin-associated hypersensitivity in patients randomized to the PLD-containing program (Table 5).

We consider this approach to be preferable to the random-effects model, which can give too much weight to smaller trials that are often of poorer methodological quality.