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We may have identified, in a much smaller region, genetic markers of the predisposition to such epigenetic alterations and, because a mismatch repair gene, MLH1, is involved, microsatellite instability invariably develops.
Although we considered a promoter region of length 700 nucleotides (from -600 to +100), all motifs were found in a much smaller region, between around -150 and +100.
A limitation of our study is that we only have 1 genomic/WGA sample pair for each of the capture experiments, and the chr12 experiment captured a much smaller region of genomic DNA.
On the basis of sequence divergence between these genes, the authors predicted the existence of two evolutionary strata: one large pericentric region encompassing most of the chromosome and another much smaller region distal to the mat locus.
The side of the embryo that has reduced levels of eya1 mRNA had a much smaller region of otic sensory tissue, no visible neurite outgrowth (arrowheads in Figure 4) from the sensory tissue and no visible establishment of the VIII cranial nerve.
Using the direct space approach, the spot positions are only sensitive to the flatness of the phase of the plane wave across the subset of the pattern which is responsible for each spot, which is much flatter due to it being a much smaller region of the incident light.
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The strong spine-type structure of Harrat Rahat (Fig. 1a) thus produces unusual results when this method is applied across the whole field and, in practice, much smaller regions should be assessed to look for specific clustering distances.
We wanted to test whether z-scores can also be calculated for much smaller regions, that is specific genes, and calculated gene-specific z-scores (see Material & Methods).
These data show that migratory marine populations can carry freshwater haplotypes of different sizes, including much smaller regions surrounding the key T → G regulatory change.
For clarity, much smaller regions are shown in all figures, with the origin of a template sequence defined as center position (the dyad) of the 601NPE.
For the off-the-shelf exome capture platforms that target much smaller regions (~ 200 bp), we failed to observe sufficient correlations between DOC and GC-content or bait distance (Fig. 4C and D) that would allow similar corrections.
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