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Consistently, three out of four tumors in the combined treatment have a much smaller cluster size than those with shRNA alone.
Interestingly, a much smaller cluster, Cluster 196, also enriched in endothelial cells, contains ANGPT2, HOXD1, FLT4 and SPRY1, each with known endothelial-specific biologies.
A separate, much smaller, Cluster 19, is enriched in uncultured neutrophils and BM, and contains the granulocyte colony-stimulating factor (G-CSF) receptor (CSF3R) and the transcription factor STAT5B.
Ferrinho et al. (2009) note that in 2008 foreign doctors in Portugal belonged predominantly to two clusters; the main one including doctors born and trained in low-income countries with physician density lower than the Portuguese (mostly from former Portuguese colonies), and a much smaller cluster from wealthier and physician-rich countries [ 17].
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As shown in Additional file 5: Figure S2, the partially rewired networks have diameters similar to the true combined networks, but the former have much smaller clustering coefficients.
It can be seen that by using the default parameters, MCODE produces much smaller clusters than GLay, leaving majority of the nodes unclustered.
However, charge localization and subsequent electrostriction in large helium droplets may result in the ejection of the dopant ion, solvated in a much smaller helium cluster.
Finally, in PD4107a a much smaller mutation cluster with similar mutational characteristics and associated with genomic rearrangements was observed on chromosome 12.
In addition to these 3 big recombinant clusters, there were also exits several much smaller recombinant clusters including only 2 or 3 recombinant sequences (indicated by triangles).
In this sense they have some similarity to the much smaller globular clusters.
This value is much smaller than clustering percentages obtained for gene expression in T. reesei under other conditions such as conidiation [ 24].
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