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On the other hand, particles based on PLGA-capped showed a much slower release and exhibited incomplete release, accompanied by the presence of an insoluble residue remaining even after 180 days.
The intracellular trafficking study using confocal laser scanning microscopy combined with fluorescence resonance energy transfer (FRET) revealed that the TCMs could readily release the siRNA payload within cells, which was in contrast to the DCMs exhibiting much slower release profile.
4′-Methoxylated-BDE-49 (10 μM) added to the Ca2+-loaded vesicles under identical assay conditions elicited a much slower release of Ca2+ than the parent congener, and these effects were blocked by RR (see Supplemental Material, Figure 2B, middle).
Subsequently, Plant et al. (1987) described a three-compartment system to explain rapid membrane uptake of BaP from lipoproteins and phospholipid vesicles and for the much slower release of BaP from the cell membrane to intracellular sites.
Their kinetic behavior distinguishes them from the other mutants as illustrated in Figure 4, which compares the SPR interaction curves of two receptor mutants exhibiting fast release and one of the high-affinity mutants N96W with much slower release of IFN- γ-SC.
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It is thought that there is likely to be a hierarchy of kinetics of release of platelet granules, with δ-granule release being a rapid event, followed by α-granule release and finally, by much slower lysosome release.
In the Colts' 34-7 loss to the Texans, the offensive line, with center Jeff Saturday the only starter playing in his normal position, could not protect Collins, who is much slower to release the ball than Manning is.
SAIB-MSs have a much slower drug release rate than that of MSs or SAIB ISFIs.
System 3 is more challenging to assess, as the timeframe in which sequestration has occurred is longer and it does involve re-release of carbon that was sequestered a long time ago and would have been used for other things or could have stayed in place often for several years, with a much slower carbon release (e.g. through decomposition), if not used for bioenergy provision [7, 39, 43, 44].
For AlkA-catalyzed excision of hx, kchem appears to be much slower than release of the abasic site.
Release profile showed a significant difference between rapid release of free curcumin and much slower and sustained release of curcumin-loaded micelles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com