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In contrast, lcSSc has a much slower onset.
Rosiglitazone, as pioglitazone, has a much slower onset of effect; this is also true, although not generally appreciated in clinical practice, of metformin (Fig. 2).
By contrast, both MDA/RLN2 clones revealed much slower onset and progression of tumour growth as compared with MDA/EGFP control cells.
Mice treated with DCA displayed much slower onset of CIA and significantly lower severity (P < 0.0001) and much lower frequency (36% in DCA group vs. 86% in control group) of arthritis.
Whilst the dominant response to extracellular ATP/ADP showed characteristics indicative of P2X receptor activation, there was also a very small component of the response with a much slower onset.
Similar(55)
CTS showed that subjects with a 2 4 weeks run-in period had a much slower (by 3 4 weeks) time to onset of efficacy and lower response rates in active and placebo compared to the main group or to those with a run-in period of 4 8 weeks (active-placebo of 19%, 26%, and 24%, respectively).
As the onset of action was much slower than that of the widely used Ca2+ channel blocker La3+, the GSK compounds may have restricted access to their site of action.
In Case I, we showed how a population of cells, each displaying a sharp onset of activity and a much slower decay of the extracellular field, could give rise to a Brownian power spectrum.
The physical onset of this stimulant is much slower than caffeine, but it is non-addictive.
In relapsing onset multiple sclerosis, the disability progression during Phase 1 was much slower, and that during Phase 2 was somehow slower, than in progressive onset multiple sclerosis.
Notably, both the onset and offset of metformin inhibition are much slower in cells than in isolated complex I, suggesting that they are limited by slow transport processes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com