In any case, it is much simpler to estimate a scalar N opt, rather than accurately estimating matrices Q n and R n as is required in the Kalman filter.
We remark also that when the strong condition A3 holds, then the proof of the second derivative estimate is much simpler and already follows from [15]; see also [19].
Additionally, the simplified APQ is much simpler, avoiding the problem of estimating the underlying genuine user PDF.
However, the time and effort required to build such models seem unwarranted when there now exists a much simpler method capable of producing accurate estimates of body surface area in only a couple of minutes.
In this section we show how to use the moments of generalised Cochran heterogeneity statistics to produce a point estimate of the residual between-study variance and a much simpler method for quantifying the uncertainty in this point estimate.
Other distributions such as gamma distribution give a much simpler and convincing shape, but still over estimates the peak of the distribution.
Fitting a serial dilution curve needs only three parameters, which is much simpler than fitting the response curve, which requires estimating the protein concentrations as additional parameters.
Something much simpler is.
