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That was the only reason – too much replication.
The size of the effects must be detected and the noise of the process (how much variation it has) will dictate how much replication is needed.
First, the denominator of the t-statistic, which estimates the variance of the comparison, is known to be less accurate when there is not much replication.
Choice chamber experiments seem to reflect female mating preferences, but given the low individual consistency of female choice and the low between-female agreement [13] much replication is needed to obtain reliable estimates of male attractiveness.
It would be useful to try to estimate how much replication efforts will cost, and where this funding will come from.
The hippocampal projections to the MBs and anterior thalamic nuclei arise from different cell populations (Wright et al., 2010) so it is not clear whether the same information is being conveyed (Tsanov et al., 2011) and, therefore, how much replication there is in the system.
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"The focus is very much on replication," he says.
However, in cells with a much faster replication cycle, endosomal remodeling should contribute significantly as an immunoevasion mechanism.
In agreement with previous results from V. cholerae [ 15], this indicates a much earlier replication start for the large chromosome while termination for both chromosomes occurs within a short time span.
No difference in GC content was detected between left and right arms (Fig. 2), as compared to what was observed for L. kluyveri chromosome C left arm [ 15], presenting a 10%% GC enrichment and a much earlier replication pattern.
These studies typically involved sequencing the coding regions of several candidate genes in a few hundred cases and controls followed by the direct genotyping of putatively associated variants in a much larger replication cohort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com