Those few Itk null CD4+ T cells that receive a high enough signal could express the appropriate levels of Th-POK and are allowed to continue their differentiation, which occurs at much reduced frequency in the absence of Itk.
When pollen from eif3h−/eIF3h+ FTL567/+ heterozygotes was germinated in pollen germination medium, the non-fluorescent (i.e. eif3h mutant) pollen germinated at a much reduced frequency compared to fluorescent (i.e. eIF3h+ wild-type pollen (Fig. 4A, B, Table 1).
Mavacoxib is unique among NSAIDs because its combination of low clearance and relatively large apparent volume of distribution mean that it has a plasma half-life that is much longer than those of other NSAIDs, leading to a much reduced frequency of dosing.
It is important to note that many of these microdeletions seem to act as risk factors rather than as the sole underlying cause, and that some microdeletions are found in people without epilepsy or a family history of epilepsy, although at much reduced frequency (Sisodiya & Mefford, 2011).
The therapeutic choice of four second premolar extractions (Protocol 4) demonstrated a much-reduced frequency in all evaluated intervals (Table 1).
Consistent with these data, DAPI labeling experiments revealed a much-reduced frequency of mitoses in p56Lck-deficient compared to p56Lck-expressing Treg cells (Figure S1C).
However, we found a much reduced transmission frequency of the cop1-5 mutallelelele when compared to the COP1 wild-type allele, thus making the analysis of segregating populations ambiguous.
The consequences of continuing HU therapy in the presence of mild to moderate neutropenia when haematological monitoring is either not possible at all or based on much reduced sampling frequency, is not known.
Other complement proteins show much reduced mutational frequencies [ 3, 32].
Most of our studies were conducted using the labeled protein because this protein has a much reduced absorbance in the region of interest here, the C2=O stretch of pyruvate, which lies at multiple frequencies but near 1680 cm 1 (see Figure 3).
