Sentence examples for much reduced activity from inspiring English sources

While the Leu34Glu mutation showed little effect on the function of IL-3, the Leu34Gly mutant showed much reduced activity than the wild type IL-3.

In further dose-response studies, FL-A3B WT and FL-A3B E68A mutant (CD1 mutation) showed similar activity within the tested protein concentration range, whereas A3BCD2 WT alone showed much reduced activity in the tested concentration range.

Importantly, while we again found that pre-incubation of the immunoprecipitates with ATP did not alter Nek8 activity, we did find that freezing cell extracts prior to immunoprecipitation led to much reduced activity (data not shown).

Finally, others have expressed IP3R with mutations in sites that are phosphorylated by PKA and shown that the Po of the PM cation channels activated by adenophostin A is increased by forskolin (to activate PKA) for wild-type IP3R; IP3R with phospho-mimetic mutations are hyperactive, and those with mutations that prevent phosphorylation have much reduced activity (141).

Txnip promoters with a singly mutated CCAAT box exhibited much reduced activities but nevertheless retained the induction potentials by NAD+ or glucose; however, when both CCAAT motifs were mutated, the induction potentials were completely abolished (Figure 7).

Compared to NM-212, the Ceria NM-211 had considerably smaller primary particles, larger specific surface, significantly fewer organic contaminations on the surface, and much reduced photocatalytic activity.

Although nucleoside reverse transcriptase inhibitors (NRTIs) are potent inhibitors of HIV replication in macrophages, 195 PIs show reduced activity requiring much higher dosages for a desirable effect; a feature that could be attributable to P-gp-mediated drug clearance.

Chou et al. [ 41] found reduced activity of eNOS only in the aortas of WKY and that in much older rats (63-week-old).

This research led to the identification of N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl N-{ 3-exo -8-[ 6-fluoro-2-naphthyl

As shown in Fig. 1A, weak residual palmitoyl-CoA oxidase specific activity was present in patient 1 fibroblasts, although much reduced, whereas this ACOX1 activity was undetectable in patient 2 fibroblasts.

"The last thing we want is someone with obesity to develop arthritis in a large joint, because then their options for physical activity are much reduced".