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And several much potent compounds were studies in vivo to profile their pharmacokinetic properties.
They were much potent than the reference drug ddI (EC50 = 76.0 μM) and comparable to 3TC (EC50 = 2.54 μM).
Although they are not as much potent antioxidant as ascorbic acid but their antioxidant properties can be increased by attaching suitable substituents with the quinazoline nucleus [55, 56].
Some of the multimers exhibited much potent antiviral activity against H1N1 virus (A/WSN/33), even equivalent or superior to oseltamivir.
Together, this work provided a much potent KCNQ1/KCNE1 channel peptide inhibitor so far, and highlighted the role of molecular strategy in developing potent peptide inhibitors for the natural toxin-insensitive orphan receptors.
The novel NCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low micromolar concentrations with Ki values ranging from 0.211 to 4.57 μM as compared with well-known agents.
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On both types of receptors, epibatidine is very much more potent than ACh (by more than 6000-fold), whereas carbachol is much less potent (by about 10-fold, see Table 3).
The principle behind dilution is simple: putting a tiny bit of a strong drug into a large amount of water makes it much less potent.
"We think it will be much more potent next season.
None of that proves that Clemens used B12 or lidocaine or something much more potent.
When all the receivers are clicking together, that will make our offense that much more potent".
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