In addition, the identification of new biological pathways may aid in the identification of much needed biomarkers for future trials of disease-modifying drugs.
In view of the weak evidence regarding treatment of missing upper laterals, prospective clinical trials are much needed to give further light and guidelines to clinicians.
Recently published international recommendations regarding ethical conduct in cluster-randomised trials are much needed.
Prospective data from adjuvant trials are much needed in order to answer this question (Rutgers et al, 2011).
Notwithstanding the difficulties underlying the execution of this type of complex clinical trials, larger and methodologically more robust trials are very much needed to confirm the findings of the present review, and to further identify characteristics of successful programs.
Although this excellent clinical trial provided much needed information, the authors enrolled subjects if the tick bite occurred within 3 days of their clinical visit, but did not analyze the data based on the exact time between tick removal and delivery of prophylaxis.
The VITAH trial will lend much needed data to the literature pool, and moreover conclusions drawn from this trial will provide quality evidence towards the current equipoise which exists within the discussion of the clinical efficacy of vitamin D in reducing cardiovascular-specific risk in this growing vulnerable chronic patient population.
This pragmatic randomised controlled trial will provide much needed evidence on the clinical effectiveness of post-operative night splinting in patients who have undergone fasciectomy or dermofasciectomy for DC.
In doing so this trial will provide much needed data on the efficacy of self management interventions with respect to clinical and psychological outcomes that can inform clinical practice and health care services.
Ultimately, this trial will add much needed, controlled, prospective data to the field, and if positive, lead the way for a larger study focussed on addressing patient level outcomes in this challenging population.
