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Our study provides a molecular framework to study the enzyme mechanisms of HPPK and DHPS, and to design novel and much needed therapeutic compounds to treat infectious diseases.
pylori vaccines to date, a better molecular understanding of factors important in persistence should contribute to development of new, much needed therapeutic approaches.
However, the available preliminary data suggest that it may potentially provide a much needed therapeutic option for patients with imatinib-resistant CML.
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Additionally, although much needed novel therapeutic approaches for MM are being developed and explored in clinical trials, there is a critical need to invest in prevention research, in which there is a great opportunity to reduce the incidence and mortality from MM.
Leptin antagonists have been developed for clinical use and leptin and its associated pathways may also provide much needed novel therapeutic targets for gastro-oesophageal adenocarcinoma.
The existence of resident human lung stem cells now opens up new possibilities and questions, the answers of which will bring us closer to deliver much needed new therapeutic options for patients suffering from CLD.
Such dual control of the two pathways by NRF-1 place it as critical gene in the design of therapeutic modalities much needed to cure or better manage type 2 diabetes.
These studies may shed light not only on the cellular origins of 2q23.1 microdeletion syndrome but also other related neurodevelopmental disorders and may provide much needed avenues of therapeutic development.
Deciphering of the patho-physiological mechanisms of these common diseases promises to bring the much needed knowledge for pharmacological treatments and therapeutic interventions.
Moreover, apicomplexan-specific adaptations of the ubiquitylation pathway may represent new therapeutic targets for much needed drugs against apicomplexan parasites.
In head and neck cancer patients, new therapeutic strategies are much needed for the treatment of recurrent tumors given the limitations of conventional therapies.
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