People with more severe depression were helped by antidepressants; it is the people with much milder cases of depression who were less likely to benefit.
Though still increasing as a function of μ, its variation with the mutation rate is much milder than in the case of optimized populations, as the corresponding exponent ξ = 0.13 ± 0.04 indicates.
For instance, Duchenne muscular dystrophy is generally caused by frame-shift mutations in the dystrophin gene, whereas in-frame deletions of up to 50% of the central portion of the gene cause Becker muscular dystrophy, a much milder myopathy, which in some cases can remain asymptomatic to old age.
In the study showing a much higher proportion, milder cases of lipodystrophy that did not require a regimen change, were also recorded [ 16].
Some treated mice did show joint damage with some inflammatory infiltrate and erosion of cartilage, but these cases were much milder than the majority of CCIA control mice and bone architecture was never completely lost (Figure 2A).
Such a mode of erosion damage was similar to the case in laser surface-melted MAB, but at a much milder degree, consistent with a higher erosion resistance in the case of LSA.
Of note, the phenotypes in these cases consist of a slowly progressive and much milder clinical course with slowly worsening spastic gait with peripheral neuropathy and mild ataxia with absent or mild cerebellar atrophy in the latter and ID and predominant peripheral neuropathy in the former.
For the purpose of illustration, we show an extreme case of this phenomenon, but the effects we normally observe are much milder.
Effects are more severe for fetuses and children, and are much milder for the elderly – unless that one Sievert is delivered over a very short timespan, in which case radiation poisoning leads to death within days for anyone.
Non-prion patients showed, compared with healthy controls, a reduction in NAA/Cr in the thalamus, much milder than that detected in prion patients, but a reduction to a similar degree to the prion cases in the striatum.
