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Butylated hydroxytoluene (BHT) has a much lower toxicity and is a common antioxidant in foods.
Notably, without the targeting ligands attached, UAN nanoparticles were largely precluded from non-specific uptake by the cells, resulting in much lower toxicity.
Taken together, the novel polymer FPBAE with both excellent gene transfection efficacy and much lower toxicity could serve as a desirable gene vector.
With the liver cells, TMZ showed a much lower toxicity to GBM cells under both 2D and 3D cell culture conditions.
Furthermore, epithelial integrity study showed that EFdA-loaded film had a much lower toxicity to HEC-1A cell monolayers as compared to VCF®.
Studies concord in finding organic food much less contaminated by pesticides, and with residues of much lower toxicity compared to those found in conventional foods.
Similar(43)
Their reports showed that, as compared to asbestos, CNTs have much lower inhalation toxicity.
Furthermore, such studies do have the possibility of identifying specific cancer targets, with higher effectiveness of chemotherapy and much lower general toxicity.
In addition, novel therapeutics in LN have all been designed to more specifically target only certain aspects of the immune system, with a goal of producing good outcomes with much lower therapeutic toxicity.
Moreover, as the DTIC dose given (800 mg m−2 q4wk) is lower than the one usually administered to patients with metastatic melanoma (Mouawad et al, 2010), this might have also resulted in a much lower haematological toxicity compared with full-dose DTIC.
Importantly, the CB-sensitive conjugate indicated a similar in vivo efficacy with the Taxol control, but much lower in vivo toxicity at the same doses evidenced by body weight, animal status, liver toxicity and blood count.
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