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We could clearly observe this phenomenon, where for example in comparison to MC-UPGMA the single-linkage clustering algorithm BLASTClust produced clusters of much lower specificity (i.e. too large clusters) at similar levels of sensitivity (data not shown).
TPA showed much lower specificity than CA15.3 and CEA.
This test has a high sensitivity (78 to 100%) but a much lower specificity.
First, amplified, multiplexed libraries tend to show much lower specificity [ 22].
Accordingly, these immune assays can be expected to display much lower specificity, since only antibodies of the IgG class against PF4/heparin complex can activate platelets [ 13].
Monitoring of microsatellite DNA instability (MSI) in tumor cells provides good sensitivity but much lower specificity for the diagnosis of the syndrome.
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As compared to method 4, methods 2 (cut-off based on reference signal intensities) and 3, exhibited much lower specificities (81.61% for method 4 and 19.79% and 7.85% for methods 2 and 3, respectively).
The predictive values of full-term infants' status from INFANIB were relatively high at ages of 7 and 10 months but, again, were much lower for specificity and PPV at 3 months (Table 4).
Other authors have reported much lower sensitivity and specificity of the PSI [22, 24].
The studies showed a much lower sensitivity and specificity for non-mass-like enhancement lesions compared with masses and suggested the need for more advanced algorithms for the diagnosis of non-mass-like enhancement.
IDBA-Tran had the highest sensitivity (42.08%) and specificity (22.94%) while other assemblers had much lower sensitivity and specificity.
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