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Cotransfection with WT Ankrd2 caused significant repression of Gsk3 β promoter activity, whereas mutant Ankrd2 resulted in a much lower repression.
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As shown in Figure 3B, LANA was able to repress the activity of the IL-22R1 WT promoter in a dose-dependent manner, whereas it had a much lower effect on the repression of pIL22R1ΔLBS-like and minimal effect on the activity of pIL22R1-mLBS-like.
Gli3 on its own gives much lower activity but it appears that repression of Gli1 is a more pronounced effect (3 4 times Gli3 induction vs. 6 times repression).
That is, higher levels of PER and TIMΔNLS in the mutant are associated with levels of repression that are typically seen in response to much lower levels of total accumulated PER and TIM in wild-type flies.
In clones 2 and 17 where ERα expression was much lower, the activating effects of unliganded ER were greater than the repression effects of E2-bound ERα, but both were statistically significant (P<0.01 and P<0.05).
In our study, we observed that the cyclin E protein produced in ED-1 cells was much lower than that observed in A549 cells (Fig. 3a), that may indicate the repression of the cyclin E expression caused by the restricted SP-C promoter in ED-1 cells.
They cannot sink much lower.
Are their risks much lower?
Others have much lower rates.
Others estimate much lower costs.
But how much lower?
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