Sentence examples for much lower potency from inspiring English sources

However, the C-terminal 12 amino acids have been previously shown to be important for actions on some tissues, as GIP1 30 exhibited much lower potency than GIP1 42 for inhibiting gastric acid secretion from the perfused rat stomach [54].

Interestingly, Nakashima et al. found that cucurbitacin I had much lower potency than cucurbitacin E in inhibition of cofilin phosphorylation and effects on actin [31], which may suggest a different profile of specific cellular targets.

Consistent with the previous study of Werts and co-workers [13], the heat-killed host-adapted serovar Bataviae isolate displayed a much lower potency to stimulate THP-1 cells compared to the corresponding heat-killed culture-adapted Bataviae serovar.

Paradoxically, silencing a portion of Mov10 expression in producer cells also reduced infectivity of HIV-1, albeit with much lower potency compared to inhibition seen in over-expression experiments.

In general, tested compounds had a much lower potency within our cellular assays compared to results obtained with purified enzymes.

However, paroxetine and its derivatives reported thus far still have much lower potency against GRKs than "off-target" serotonin transporters, emphasizing the need to identify alternative chemical scaffolds.

However, much lower potencies were observed for hGPR17-L with a 50- to 170-fold increase in EC50.

Interestingly, the engineered protein was found to exhibit much lower neutralization potency than its wild-type counterpart, indicating that potent antigen recognition is not solely responsible for IgM-mediated HIV-1 inactivation.

Taking into account the much lower estrogenic potency of BPA, it is obvious that BPA does not contribute to a biologically relevant extent to the total estrogen exposure during pregnancy.

This likely also explains the much lower antiprotozoal potency exerted by the O 6 -benzyl-2-methyltriazenyl purines with activityr activity (see Fig. S5 in the supplemental material) (31), consistent with the antiprotozoal activity being principally determined by effective uptake via the nucleobase transporters.

Furthermore, the bovine TAAR3 did not show any detectable activity and even the rat TAAR3, which is 95.6% identical to the mouse TAAR3 protein, exhibited much lower efficacy and potency to both agonists (Figures 4A, B).