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This occurred because the absolute amount of paclitaxel getting into the tumor was much less due to much lower plasma exposures following nanosuspension delivery (Table 1).
The low-polarity ergostanes antcins B (9/10) and C (3/4), containing zero or one hydroxyl group, respectively, could also get into circulation, though exhibiting much lower plasma concentrations.
Absorption was slow and variable and much lower plasma levels were observed than after oral dosing.
It was also shown that older patients required much lower plasma concentrations of benzodiazepine to achieve levels of sedation comparable to those in younger patients.
We observed rapid and extensive distribution of quinacrine in brain, liver, and spleen tissue in association with much lower plasma concentrations.
The subsequent terminal elimination half-life (beta phase) was approximately 10 20 h, with detection of much lower plasma levels (0.01 0.03 ng/mL at 36 h post-removal).
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A regular combustible cigarette usually delivers a nicotine peak of 18 20 ng/ml in blood plasma shortly after smoking; one early study of e-cigarette use by naive e-cigarette consumers observed much lower peak plasma nicotine values of 1 3 ng/ml [43].
First-dose VGB concentrations in brain microdialysates were highly variable between patients and much lower than plasma VGB concentrations (Table 1 and Figure 2).
The MPM brain AUC is much lower than plasma AUC for the two patients enrolled, consistent with the PK theory in the presence of tissue with efflux transporters.
For each of the two patients, the MPM brain AUC is much lower than plasma AUC and accordingly brain to serum AUC ratios are respectively 0.73 for Patient 1 (P1) and 0.14 for Patient 2 (P2).
However, the animal that lost the MHC class I-silenced cells at week 7 shows much lower IgG plasma levels than the rats that rejected the MHC class I-expressing cells at week 3.
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