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An in-furrow application of a granular insecticide has a much lower efficacy than the T-band.
Many of these differences are explained by correcting for the high agonist efficacy of GABA at most αβγ receptors vs. much lower efficacy at αβδ receptors.
An AAV2/9 vector containing the MHCK7 cassette corrected GAA deficiency in the distal hindlimb, and glycogen accumulations were substantially cleared by human GAA (hGAA) expression therein; however, the analogous AAV2/7 vector achieved much lower efficacy.
Furthermore, the bovine TAAR3 did not show any detectable activity and even the rat TAAR3, which is 95.6% identical to the mouse TAAR3 protein, exhibited much lower efficacy and potency to both agonists (Figures 4A, B).
The implementation of the same intervention in high transmission regions (parasite prevalence above 80%) (Figure 5B,D), indicates much lower efficacy in protecting against clinical episodes (blue line in panel B), but significant rebound in the age range under treatment (red line in panel B).
However, when tested in efficacy trials in Africa and Asia, these two vaccines showed much lower efficacy [ 38, 39].
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In fact, we would not want to use a model empirically calibrated to older data, reflecting much lower treatment efficacy, to inform current policy questions that could contribute to decisions in the future.
Cells seeded on bovine cancellous bone demonstrated a much lower seeding efficacy and proliferative activity in comparison to cells seeded on β-TCP [ 42].
Through the development of a communication tool (a "balance sheet" summarizing published evidence on benefits and possible adverse effects of vaccination) to enable communities to balance costs and benefits of measles vaccination, Ledogar et al [ 13] uncovered a much lower vaccine efficacy rate in Lasbela, Pakistan, than expected.
This is in an excellent agreement with our data in the tail-flick analgesia test and recent work, which showed that EM2 has a much lower operational efficacy for G-protein mediated responses than DAMGO at native mu-opioid receptors in mature neurons [ 40].
The main limitation of the model is that the efficacy of the vaccine is not known (we made the assumption that the efficacy of the vaccine against gonorrhea was likely to be much lower than its efficacy against serogroup B meningococcal disease: 20% vs 78%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com