Osteoporosis patients, on the other hand, usually take bisphosphonates as pills, in much lower doses.
Whether much lower doses than those used in the experiments would benefit athletic performance is not clear, Dr. Evans of the Salk Institute said.
But large doses of resveratrol are required to show any effect, so chemical mimics like SRT-1720 were developed to activate sirtuin at much lower doses.
As Andrew Pollack reported in The Times on March 16, some experts believe that much lower doses of Cerezyme would still be medically effective and could save the health care system more than $200,000 a year per patient.
Sirtris Pharmaceuticals, of Cambridge, Mass., is now conducting clinical trials of resveratrol, in a special formulation, and of small-molecule drugs that also activate sirtuin but can be given in much lower doses.
Even when psychiatrists use sedative drugs like sodium amytal during an interview, in much lower doses than are used for anesthesia, it is unclear whether patients are telling the truth or spinning tales.
Sirtris, a company Dr. Sinclair helped found, has developed a number of chemicals that mimic resveratrol and are potentially more suitable as drugs since they activate sirtuin at much lower doses than resveratrol.
The law's challengers point out that standard medical practice has changed and doctors routinely prescribe the drugs differently now (at much lower doses and two weeks later into a pregnancy), which is fully permitted by federal law.
Children, drinkers and the severely undernourished are potentially at risk at much lower doses than 20 grams.
(Both Ikaria and Roth say the gas can exert organ-protective effects even at much lower doses).
Furthermore, for SPEs internal organs received much lower doses with respect to skin, and nuclear interactions were found to be of minor importance.
