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Much lower dosages were adopted in the chronic toxicity assay in order to imitate the human clinic medication practice of XF and PXF.
A combination of TFEB-targeted therapy with ERT, perhaps at much lower dosages than those currently employed (and therefore at reduced cost), could then maintain muscle tissue in normal or nearly normal condition.
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Compared to the non-encapsulated drug, mice treated with erythrocyte-encapsulated doxorubicin showed significant inhibition of metastatic growth in liver and lung at a much lower dosage.
In 2005, a study from Taiwan showed that lanthanum carbonate could achieve a −0.7 mmol/L mean difference compared to placebo with a much lower dosage of 750 1500 mg/d [ 17].
It is worth noting that basal striatal CBF was unaffected by 7-NI injection in the present study, which might have been due to the much lower dosage of 7-NI used.
As shown in Fig 3, AbS4A maspin antibody did not block STS-induced cell apoptosis at concentrations up to 1 μg/ml (1 200 dilution), even though the same antibody was effective at blocking maspin's effects on cell migration at a much lower dosage (data not shown).
One explanation for the discrepancy between this study and previous ones is the different dosages of phthalates: we used a much lower daily dosage (100 mg/kg) than the previous studies (500 ~ 1000 mg/kg).
These concretes with high strength and low shrinkage can be prepared with much lower cement dosage compared to the conventional process.
These materials would be much more energy efficient and would subject patients to a much lower radiation dosage.
At a much lower enzyme dosage of 0.044 g CTec2 enzyme product/g dry (unwashed) pretreated softwood, hydrolysis at 17% solids achieved 9.2% total sugar titer in the hydrolysate with an overall sugar yield of 85.0% in the combined prehydrolysate liquor and enzymatic hydrolysate.
The dosage of B401 extract given was much lower than the dosage of IC50 for mice.
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