Sentence examples for much lower binding from inspiring English sources
These PQAs showed binding to pyrimidine bulge DNAs and CNG (N = T and C) repeats depending on the linker structure, while quinoline derivatives lacking the pyrrole ring showed much lower binding affinity.
The essential role of Phe313 and Trp305 in N-6 binding was confirmed by our SPR assays, showing that N-6 had much lower binding affinity to two RXRα-LBD point mutants with Ala substitution of Phe313 or Trp305 (Fig. 4D and 4E).
By contrast, the ANTXR1 I domain-PA interaction exhibits a much lower binding affinity (KD = 130 nM) [20].
Meanwhile, LILRA3 displayedyed much lower binding affinity to HLA-A*0201 HLA-A*0201 µM) but still reached the binding affinity range of CD8 (∼100 µM).
We found that ZE2 aptamer binding to the HCV particles was aptamer dose-dependent, but the ZE3 aptamer or the ZE2-mut with two mutated bases had a much lower binding affinity (Fig. 4A).
Further, upon expressing a mutant allele of the Ste5 scaffold which has a much lower binding affinity for Fus3, the ultrasensitive response of Fus3 is converted to a Kss1-like graded response.
However, construct #2 containing 3 times higher amount of anti-HBsAg scFv molecules showed much lower HBsAg-binding activity in ELISA and HBV-neutralizing potency in the in vitro HBV infection assay as compared to construct #1 harbouring Fc-engineered scFv molecules.
Wild-type A. pleuropneumoniae in the early exponential or stationary phases bound to DNA, but the numbers of bacteria binding to DNA in these growth phases were always much lower than those binding to Fn (Fig. 8).
Binding to nucleosomes was seen at much lower concentrations than binding to dsDNA (compare Figs 3 and 4).
Table 1 also indicates that, except for 1RBP, where the score of the all-atom model is much lower (predicting less binding affinity) than the score of the polar-hydrogen model, both models produce similar scores.
The tumour uptake of the 99mTc-HYNIC-PEG4-dimer was much lower, suggesting monovalent binding.
