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The major factor that is rarely taken into account is the intrinsic rhythmicity of hypothalamo pituitary adrenal activity, not simply the classic diurnal variation but also the endogenous pulsatility which is similar to, but much less well recognized than, the rhythms found within the reproductive and growth hormone axes.
These diseases are much less well recognized even than HAM/TSP, with no data on incidence or prevalence among carriers.
Atrial fibrillation (AF) is a significant independent risk factor for stroke, associated with an approximately five-fold excess in risk, but is much less well recognized than, for example, hypertension, for which the excess stroke risk is three-fold.
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Migraine is also a major public-health problem worldwide, although less well recognized.
However, selection bias due to improper case sampling is less well recognized.
Depending on the region, pastoralists' usage rights are more or less well recognized at the level of the attachment territory.
What is less well recognized is why all humankind has a big stake in the success of that project.
Some are of course self evident and also well researched, while others probably are less well recognized, or less recognized as to their possible importance.
However, it is less well recognized that tissue hypoperfusion can exist despite normalization of systemic hemodynamics.
Less well recognized is their role in immunity to other microorganisms.
In comparison to the polymer forming ARTDs, the mono-ARTDs remain much less well understood, mainly because they have only recently been recognized [ 3] and because basic research tools such as antibodies recognizing mono-ADP-ribosylated residues are lacking [ 22].
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