This pathway seems to be disrupted, or at least much less tight, in other cell lines of malignant and transformed phenotypes, but so far has not applied to any of the leukaemic lines analysed.
But there is a much less tight and predictable relationship between response and outcome when individuals seek drugs in more complex, or real world environments, where reinforcement is often delayed and drug seeking must be maintained over long periods of time (Everitt & Robbins, 2005).
After the emissions scandal, Volkswagen can no longer claim "clean diesel" as a brand position nor as a viable solution to meeting current emissions standards much less tighter future standards.
The producer, Don Ohlmeyer, won't let Miller overwhelm any game, much less a tight one, and Miller has no desire to be overwhelming.
These clusters, however, were much smaller and less tight than the clusters induced by L243.
ALMATY, Kazakhstan — Negotiations over Iran's disputed nuclear program broke off Saturday with scant signs of progress, much less an agreement on tighter controls demanded by six world powers in exchange for some easing of sanctions that have a stranglehold on the Iranian economy.
Indeed, it is not excluded that the damage could occur in the epididymis, where the tight junctions are much less effective than in the testis [ 26], or directly in the semen.
Because these proteins lack immunoglobulin domains, they are much less immunoreactive, and their smaller size (∼4 kDa) allows tighter interactions between the avimer and their target cytokine or receptor.
There was no genome-wide significant discovery for height, which is perhaps unsurprising given that this trait is under much tighter genetic control than weight and varies much less than weight across the adult life span.
If Rasmussen is right, though, the race is very tight in the key states and Obama would be much less of a favorite than the polling consensus suggests.
Soften the effect by teaming them with a wedge heel, opaque tights and an oversized cardigan for a look that's much less regal.
