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Note that unlike other CNG isoforms [16] which are insensitive to D-cis-diltiazem even at mM concentration, olfactory-type CNGA2 is inhibited by D-cis-diltiazem though with much less potency compared to that of L-cis-diltiazem.
Furthermore, LY2784544 effectively inhibited STAT5 phosphorylation in HEK293 cells expressing JAK2V617F and two other JAK2 mutants (H538Q and R564Q) with much less potency against the JAK2Y931C mutant.
The central domain of IGFBP-5 can bind to the acid-labile subunit with much less potency than full-length recombinant human IGFBP-5 [ 69].
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However, inhibition by the peptide was at much lower (10,000 times less) potency than inhibition by our prodomain constructs, which acted at sub-nanomolar concentrations.
Here, we report that GA inhibits tumor proteasome activity, with potency comparable to bortezomib but much less toxicity.
While it is known that IFNβ performs a unique role in viral infection and is essential for a fully effective general antiviral response, the potency of HIV-1 restriction was much less when MDM were pretreated with IFNβ.
By November, though, that argument may also have less potency.
Much, much, much, much less perfect.
Eat out much less.
How much less?
Much less appalling.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com