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In BT474-AR cells, despite expressing more Beclin1, much less induction of autophagy induction was observed by this method (cf. Fig. 2A).
In addition, the supplementary SiO2 nanoparticles displayed a greater degree of agglomeration when compared to the main SiO2 nanoparticles in the present study and much less induction of mitochondrial ROS.
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This was particularly evident in the case of the iPSC-MHF2 c2 line (Figure 2A), which showed much less effective induction of retinal genes than any of the other lines.
A much less pronounced induction of cell growth-promoting genes in stimulated immature B cells likely reflects their abortive attempt to proliferate, as previously described [ 9, 10].
The direct antioxidant action of antioxidant supplements seems thereby to be much less important than induction of endogenous antioxidants, especially via the Nrf-2 dependent pathway [ 105].
Importantly, mini-yCD3 was shown to be much less potent in the induction of T-cell proliferation, cytokine release (interferon-γ and interleukin-2) and early activation marker expression on the cell surface (CD69 and CD25) than parental yCD3.
M4 receptors were much less important for the induction of USVs during male-female interaction (see Figure 7B).
These later days PoI are much less relevant to the induction and development of the cerebral syndrome (which was fatal in nontreated mice 6 or 7 days PoI).
Furthermore, Elm1 is much less effective in supporting induction of invertase when only Sip1 is present compared to the presence of Gal83 in the complex.
Therefore, the required conditions for SDDP induction appear much less stringent than those for STDP occurrence.
However, the in vivo experiments, presented in Figure 3, showed that SOS induction is much less efficient in a hupAB background, as observed previously [20].
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