The envelope protein, E, is 14% disordered in the outgroup TABV, but the first clades to branch off, KRV and RBV, are much less disordered than the younger clades (DENV, ZIKV, and WNV).
AS regions in META genes are much less disordered than AS regions in other disease classes, just like whole META gene sequences are much less disordered than other disease genes.
Chloroplast (2 - 13%) and mitochondrial (2 - 19%) proteomes clearly exhibit much less disorder than nuclear ones (Additional file 1: Table S1).
As seen from their melting temperatures, they require much less energy for disordering the crystal structure and breaking intermolecular interactions to achieve molecular motion above the melt point.
In a talk on Tuesday, Dr. Susan E. Swedo, head of the panel proposing the new definition, said that many people who identify themselves as "aspies," for Asperger's syndrome, "don't actually have Asperger's disorder, much less an autism spectrum disorder".
Linkage studies have been extremely successful in elucidating the causes of monogenic disorders, but much less so in multifactorial disorders.
"At the lodge, he stood up and, in essence, told all these giants of psychotherapy that there was not a shred of evidence that what they were doing with schizophrenia patients was helping, much less curing the disorder," Dr. Fenton said.
Community twin samples are very useful for the study of subclinical traits across the continuum but much less for clinical disorders as ASD.
As expected:[ 8, 25] 1) the shift in wavelengths and GP values between ordered and disordered phase is much less pronounced than in GUVs (ordered: GP≈0.2 versus ≈0.4 in GUVs, and disordered: GP≈−0.15 versus ≈−0.5 in GUVs, compare Figures 2 and 3),[ 17] and 2) the lipid packing in non-phase-separated GPMVs (GP≈−0.05) is in-between that of the Lo and Ld environments of the phase-separated GPMVs.
We found that prevalent anxiety disorders fulfilling DSM-IV criteria may be much less co-morbid with depressive disorders than previously thought if the disorders are assessed with different diagnostic instruments.
Anxiety: We found that prevalent anxiety disorders fulfilling DSM-IV criteria may be much less co-morbid with depressive disorders than previously thought if the disorders are assessed with different diagnostic instruments.
