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There are two exceptions, however, which make the above summary much less disappointing: acute phase reactants, especially CRP, are highly reliable markers of disease activity and, in the long term, radiographic outcomes; and auto-antibodies, especially rheumatoid factor and autoantibodies to citrullinated proteins, have diagnostic and prognostic value.
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It doesn't make the disappointment any less disappointing, nor the rage any less real.
The report on how many jobs were added during the month — which got much less attention in those days — was strong in January 1983, and disappointing last month, when it showed an increase of 103,000.
But what's more disappointing is the administration's failure thus far to even acknowledge (much less ask Congress for) the kind of funding that will be needed to put the developing world on a low-carbon pathway.
Get an unacknowledged switched vintage on a Bordeaux order, and you may not only drink a disappointing wine but pay top dollar for a bottle the restaurant bought for much less.
I figured maybe if I got this Chakrub and actually took it seriously, I could accomplish some much needed healing, which would in turn help rid me of my anxiety and make my love life less disappointing.
Prince Guillaume is a less disappointing role.
Much, much, much, much less perfect.
How much less?
Much less appalling.
God, much less bigotry.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com