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In terms of sequence conservation, PGx variants are more conserved than neutral variants and much less conserved than disease variants.
Overall WMIs are more conserved than average, yet they are much less conserved in the random networks.
In the first motif, bases from the third to the last position, ACAGC, are well-conserved, but the first two bases, TC, are much less conserved.
Especially, the first 16 N-terminal and the last 10 C-terminal residues in the LysM motifs are well-conserved, while the central region (residues 17 34) is much less conserved, except for the residues at positions 23, 27, and 30 (Fig. 1a, Buist et al. 2008).
The N-terminal region is much less conserved than the kinase domain but interestingly, clear ortholog pairs with very good conservation were identified.
Nitrogen cycle gene families were much less conserved among ecozones, with only nine families, corresponding to three functional types (nifH, nirK, and norB), found in all ecozones.
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In comparison to canonical histone H3, CenH3 is much less well conserved [16], [17].
It is evident that prior to about position 130 in the alignment, the N-terminal region is much less highly conserved.
We note that not applying any distance cutoff for defining a pair of adjacent genes means that genes with much longer intergenic distances will be included for which the micro-synteny is expected to be much less evolutionary conserved thus potentially biasing our analysis.
Whereas in all-β set, the C-ter of P7 is less conserved, and P2 does not show much deviation.
Because the best hit was less conserved in non-primate mammals and much shorter in mouse and rat, we inferred that the functional domain(s) conserved in mammals should be much shorter than 1,804 bp.
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