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Note that this is despite the fact that we were assaying 9 different conditions, and accordingly, were able to query a much larger sequencing space than previous protist studies [ 64, 65].
The authors present an inverse correlation between the abundance of MSCC tags and measured cytosine methylation per regions, but recognize that a much larger sequencing effort is necessary to increase accuracy at low methylation densities.
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And Dr. Sulston then began to sequence the worm's genome, the pilot project that gave scientists confidence they could tackle the much larger sequence of the human genome.
The introduction and continued development of next generation sequencing (NGS) now allows the acquisition of much larger sequence data sets in shorter time and at lower costs compared to what was possible using classical Sanger sequencing.
Exhaustive alignment and phylogeny approaches cannot be applied to data sets with > 10 sequences, but heuristic approaches have been developed that sacrifice the guarantee of optimality for the benefit of being able to run on much larger sequence data sets.
While in the past decade there has been extensive research on sequence family clustering for handling datasets in the range of hundreds of thousand entries (e.g. Li and Godzik, 2006), there has been very limited development of methods for clustering the much larger sequence volumes from NGS experiments with hundreds of millions of entries.
A comparable percentage of sequences from the much larger 454 sequencing study [ 16] were also aligned.
The transcript diversity we found in the porcelain crab transcriptome mirrors the results of a much larger EST sequencing effort in Daphnia pulex [26], the only crustacean genome that has been sequenced to date.
Viewed in terms of parameter reduction, this is a 88.8 % reduction in parameters while actually achieving a 1.6 and 5.3 % relative reduction in WER compared to a much larger DNN sequence-trained with log-mel filterbank inputs and hard aligned targets.
Unlike the FG-binding pockets, the RanGTP interaction site is much larger and sequence-conserved, thus easier to recognize.
Yb from D. ananassae has a large number of indels relative to the other five species (and has a much larger coding sequence and an additional intron).
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CEO of Professional Science Editing for Scientists @ prosciediting.com