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A comparative study between the internally multi-staged permeator and a conventional single-stage permeator indicates that, under the same energy consumption, the former offers higher degree of separation, but requires much larger membrane area.
The next step in the analysis of TO-POPC systems will be simulations of much larger membrane patches, where it will be possible to predict the maximum size of the TO aggregates in membranes, and include steryl esters in the mixture.
So presumably not just synaptic vesicles – what other organelles could be involved in these much larger membrane fusions?
The P2X7 receptor is a unique member of the P2X receptor family, since it is only activated by high concentrations of ATP (>100 μM) and can open a much larger membrane pore than any other P2X channel [ 57].
The accuracy of intravascular microdialysis probes will vary according to their position - for example, if integrated into the central venous catheter, a much larger membrane will be possible than if positioned in a smaller peripheral vein catheter, allowing a greater area for equilibration and a more rapid and reliable result [ 19].
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Aβ peptides are small fragments cleaved from a much larger integral membrane protein, the amyloid precursor protein (APP).
Typical eukaryotic cells, by contrast, are much larger, the cell membrane constituting only 10 percent or less of the total cellular membrane.
The self-adaptive membrane module had the longest stable operation time, up to 72.3 h when operated in submerged bioreactor, much larger than other membrane modules.
However, when large aggregates of debris accumulate or during xenophagy (Kageyama et al., 2011), autophagosomes form locally on the surface of the substrate and grow in contour with the often irregularly shaped structures that can be much larger than the membrane cups formed during starvation.
We conclude that irreversible engagement of fusion peptides from 3 4 neighboring [HA1-HA2]3 trimers, within a much larger virus-target-membrane interface, leads to subsequent rearrangements that rapidly and cooperatively induce membrane merger.
The cells of the outer spinous and granular layers also contain much larger, lamellated bodies the membrane-coating granules.
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