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Particularly, the largest QD bundled NPs examined, QD655, had a much higher uptake capability and greater gene expression ability than the other QD NPs (QD525, QD565, and QD605).
The selective adsorption of nHEX over the branched isomers by compound 1 follows a similar molecular exclusion mechanism as in the case of zeolite 5 A, but having a much higher uptake capacity.
On the other hand, [(18 F]FPOBBG, a compound recently reported in the literature, demonstrated much higher uptake, albeit less than that of co-incubated [(125 I]MIBG.
The normalisation applied here compensated adequately for the influence of the much higher uptake in SKOV-3 (Fig. 4f vs. 4e).
In comparison to these previously reported studies, our in vivo experiments resulted in a much higher uptake of radioactivity in bone, which likely originates from free 18F.
Renal retention of 44Sc-PSMA-617 was comparable to the 68Ga- and 177Lu-labeled versions; however, 68Ga-PSMA-11 showed a much higher uptake in the kidneys (~60% IA/g, 2 h p.i., Fig. 4).
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Computational analysis of DOX uptake in the resistant cells showed a very different pattern: free DOX had minimal uptake, while the nanoDDS formula facilitated much higher nuclear uptake of DOX over time.
The uptake of the screening interventions in randomised controlled trials was much higher than uptake rates observed in practice [ 29, 30].
In vitro cellular uptake studies with HT-29 cells showed that the optimized curcumin-loaded PLGA nanoparticle exhibited a much higher cellular uptake of curcumin (i.e. 7.01 ± 0.33 μg/106 cells) than a native curcumin solution (3.74 ± 0.56 μg/106 cells).
In the cellular uptake study using KB cells positive for the folate-receptor (FR), FHP and FPHP nanoparticles showed a much higher cellular uptake than did unconjugated HP nanoparticles.
Compared with non-targeted NPs, the Anti-VEGF antibody modified NPs showed much higher cell uptake in the HepG2 cells.
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