Exact(3)
A much higher free BPA concentration in blood relative to estradiol would not be taken into account in predicting its in vivo potency based simply on cell culture studies conducted in culture medium.
Cell culture media usually contain a much higher free glutamine concentration than does human plasma, and lowering of glutamine concentration in cell culture media is associated with a lower rate of cell division.
A possible explanation for this phenomenon may be the existence of a very thermodynamically stable stem (with free energy Δ G = -36.6 kcal/mol) that holds the 5' splice site and the branchpoint together (analogous stems in wildtype introns have much higher free energy, see Section 2.3).
Similar(57)
The activities of immobilized lipases were much higher than free lipase at alkaline pH (more than 50% at pH 12).
As shown in Fig. 5a, the MTX-PEG-CPT NRs showed much higher cytotoxicity than the free CPT, free CPT plus free MTX, and PEG-CPT NRs at the same CPT drug concentrations.
The Dutch, both men and women, place a much higher value on free time as a luxury good than Americans do.
Previous studies have found that the concentration of propofol that is required to affect synaptic inhibition in brain slices is much higher than the free concentration that is achieved clinically and that modulates isolated receptors.
Without radiation, pitting occurred only at potentials much higher than the free corrosion potentials, ie no pitting on any grain orientation has to be expected under conditions relevant for HLW disposal.
The current Model S and Model X Teslas, which are sold with much higher MSRPs, include free use of the company's extensive supercharging network.
Moreover, these metabolites seem to be present in the urine sample with high H/sH ratio (approx. 5) at much higher levels than free BMPEA.
Patients with type 1 diabetes, on the other hand, had much higher total and free testosterone concentrations that were comparable with those observed in younger normal subjects.
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