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However, while the fold up-regulation of miR-455 was similar between LPS and heat killed C. albicans, LPS gave a much higher fold stimulation of miR-155 than heat killed C. albicans (150 compared to 7 fold).
QCIMFI is activated at lower concentrations of LG335 and has much higher fold inductions than RXRwt.
Furthermore, we used FACS analysis and showed that MLN4924 induced remarkably more apoptosis in Atg5−/− MEFs than that in Atg5+/+ cells, as reflected by a much higher fold induction of sub-G1 population in Atg5−/− MEFs.
In addition, in treatments in this study where there was higher concentrations of nitrate (>2.5 μM), the transporter set MAE14790, 14780, 14770 had much higher fold change values (between 4.56 and 23.18) than MAE18880, 18890, 18900 (between 2.59 and 4.16).
It is interesting to note that significant reduction in the number of GO terms is not achieved until much higher fold change values are considered, e.g. 4 fold in Log2 scale (64 fold in normal scale), which also significantly reduces the number of deregulated transcripts included in the analysis (data not shown).
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Fig. 3 illustrates how as temperature increases, the RBS of rpoH shows a much higher fold-change in openness as compared to the regions flanking it.
If the up-regulated genes have a much higher fold-change, then the number of false positives will decrease.
Conversely, Liv-Ikk2ca mice had comparable Gadd45b, RelA/p65, and Nfkb1 (p50), but moderately higher Ikk1 and much higher (6.9 fold) RelB (Fig. 1a).
Interestingly, Liv-Ikk2ca mice had much higher (5.5 fold) Ikbke and 95%% higher NF-kB inducing kinase (NIK) which activates IKK1 [ 16] (Fig. 1a).
The FP assemblies presented at Figure 1 were performed at coverage much higher (1.7…7.9 fold) than that for the WGS assembly (38×).
The result showed that the transcriptional levels of both araD and ptk were much higher (>60 fold) in the 824ccpA compared to those of the 824WT (Additional file 7: Figure S3), demonstrating that this gene set (araD-araA1-ptk) was subject to CcpA-dependent glucose repression and l-arabinose induction.
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