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Very few sites are disordered across all taxa, while the ordered sites show much higher conservation.
However, the dEER motif seems to be of much higher conservation.
Multiple alignments revealed that ARGFX exons (and sequences immediately flanking exons) show much higher conservation than introns between divergent lineages.
Those GC-matched non-OR promoters still had much higher conservation scores than our OR-promoter set (data not shown) - it was thus not possible to match promoters on GC content and conservation levels.
We found that the ligand-binding pockets had much higher conservation than the full proteins, while the peroxisome proliferator-activated receptor γ and corticotropin-releasing factor receptor 1 were notable exceptions.
FadD22 proteins showed much higher conservation in M. tuberculosis and M. leprae than that observed for other orthologous proteins (compare Figure 1 and 3) implying an indispensability of this protein for the pathogenesis.
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Compared with introns, both conditional exons (red) and constitutive exons (black) have much higher conservations.
Genomic DNA that has been transferred between reproductively isolated species is marked by much higher sequence conservation than the remainder of the genome.
In general, earlier studies overestimated variances between species [ 35], while more recent studies using larger and more standardized datasets showed a much higher level of conservation [ 6].
Comparison of the HAdV-37 genome with that of HAdV-9, also within species D, showed a much higher degree of conservation than with representative HAdVs from other species, but demonstrated disparity in the penton, hexon, E3, and fiber regions.
Van Dam and Snel [ 17] showed that conservation rates for PPI within complexes in human and yeast are much higher than overall interaction conservation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com