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For the absolute index, composite variable ranks had a much higher concordance (Kendall's W = 0.42, P<0.0001), most likely owing to the correlation imposed by higher absolute consumption and economic activity in populous and wealthy (in absolute terms) countries (see also below).
Several investigations dating back to the 1970s indicate that identical twins have a much higher concordance rate of ASDs than fraternal twins, according to a report in the Spring 1998 issue of Mental Retardation and Developmental Disabilities Research Reviews.
Twin studies have demonstrated a much higher concordance for ASD in monozygotic (>70%) than in dizygotic twins (0-10%), suggesting genetic factors to play a major role in the etiology [ 3, 4].
There is a striking difference in results, with much higher concordance for MZ and DZ twins when impairment is categorized by SLP status, as compared to when it is diagnosed according to language test results.
Twin studies have shown that monozygotic twin pairs have much higher concordance rates for ADHD than dizygotic twin pairs 8 and adoption studies have also found increased rates of ADHD in the biological parents of ADHD adoptees compared with both the adoptive parents of the probands and with the parents of controls without ADHD (eg, Sprich et al 9).
Similar(55)
However, other partially methylated CGIs 30-700% methylation) showed a much higher variability in concordance value.
After gender stratification, no significant differences were found as compared to the gender non-stratified analysis; however, females did report much higher prevalence and concordance levels than males for all variables, also consistent with previous research [ 20, 22].
Twin studies have shown that concordance rates are much higher in monozygotic twins than in dizygotic twins.
However, Ki67 concordance rate was much higher in ER negative tumors compared with ER positive tumors (92.5% vs. 76.2%, P = 0.003).
In addition, the concordance rates were much higher for ER, PgR, and HER2 than Ki67, which again can be explained by more heterogeneous distribution within the tumor for Ki67, especially in ER/PR positive or grade 1 2 tumors.
However, T1D cohort studies have not followed twin subjects over their entire lifetime; therefore, the true concordance rate may be much higher.
Related(20)
much higher alignment
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substantially higher concordance
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much higher failure
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much lower concordance
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Justyna Jupowicz-Kozak
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