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Intratumoral injection of DPS complexes resulted in much higher accumulation and luciferase expression in the tumor bearing C57BL/6 mice.
This is a much higher accumulation than that others have observed for chemotherapeutics to date [15], [71], [72].
In contrast, we observed a much higher accumulation of sense siRNAs after heat shock in both the adr and adr rde-1 stradr rde-1
Gadovist® shows a much higher accumulation of contrast medium within the parenchyma of the tumour than the high molecular weight Gadomer®.
Although the identical heterologous expression system was used, BrCYP81F4-2 led to much higher accumulation of 1-methoxy-indol-3-ylmethyl GS.
All of these features should explain a much higher accumulation of mTHPC shortly after administration in invasive SCC as compared to normal tissue or early SCC.
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The targeted lipid prodrugs B-R-ACV and B-12HS-ACV exhibited much higher cellular accumulation than B-ACV, R-ACV and 12HS-ACV in both cell lines.
Their results indicated a much higher charge accumulation on the edges (~ 4.2 times higher than on basal planes).
Interestingly, virus infection caused a much higher increased accumulation of miRNA* sequences compared to that of the corresponding miRNAs.
The co-modified liposome had a much lower cellular uptake and tumor spheroid uptake, but a much higher tumor accumulation compared to CPP-modified liposome, indicating the non-specific penetration of CPPs could be attenuated by the outer PEG coating.
Interestingly, no histopathological changes were observed in liver and kidneys from [Pt(O,O'-acac)(γ-acac)(DMS)]-treated group mice, compared with the controls, despite much higher platinum accumulation in these tissues relative to the compound treatment.
More suggestions(15)
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